TUMOR
PLASTICITY :
A KEY DRIVER OF PATIENT'S RELAPSE

UNLOCKING PHENOTYPIC PLASTICITY

Cancer is a moving target causing:

Adapted from Hallmarks of cancer: New dimension*

CURRENT TREATMENT MUST
BE COMBINED TO BE EFFICIENT

LACK OF ANTIGENICITY

With hidden targets to the immune system

LACK OF ANTIGENICITY

With hidden targets to the immune system

BRENUS
PHARMA:

THE MISSING LINK ?

Brenus Pharma develops a next gen immun therapeutic based on adaptive & multispecific targets to educate the immune system to anticipate tumor plasticity & treatment resistance.

ENGAGE WITH US IN
A CHANGE OF PARADIGM

EFFICIENT TECHNOLOGY

Anticipates risks of tumor escape by targeting over 250 cancer-related antigens driven by relapse mechanism.

Answers huge unmet need in solid tumors : Platform strategy, combining impactful technologies, with standardized steps for a quicker generation of immunotherapy for solid tumors

DERISKED APPROACH

2nd generation of innovative cancer vaccine strategy : previous haptenized approaches show significative historical clinical DATA (Glioblastoma + Melanoma).

Preclinical package endoresed with FDA Pre-IND passed.

GMP manufacturing ready.

Top international scientific leader on board & experienced governance in Healthtech industries.

LIMITLESS POTENTIAL

IP by design-platform strategy ; 22 patent granted.

Tailored first-in-class drugs design.

Dynamic immuno-oncology market with mRNA and Personalized Cancer Vaccine.

Ensuring treatment’s availability to a wide population of patient in therapeutic issue.

STAY TUNED

INCREASE IMMUNOGENICITY

Brenus’ manufacturing process overpasses the lack of immunogenicity & educates the immune system  with visible and multi-specific targets

REPRESENT HETEROGENEITY OF THE TARGETED INDICATION

Selection criteria of starting material (Allogeneic tumor cell lines)

  • Representative oncogenic drivers (TP53,BRAF,KRAS,…)
  • Cold & hot tumor cell lines
  • Resistances capacities (metabolic ; chemical & physical)

Increase antigenicity

Brenus’ manufacturing process overpasses the lack of antigenicity & educates the immune system  with broad & higher quality range of tumor antigens