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L. Chalus

Lead Technical Operations

Pharmaceutical industry (R&D expert) & expertise in GMP Manufactruing .

Lionel Chalus (Ingineer) brings 25 years of experience in the pharma industry with roles at Shering-Plough, Genopoïetic, Valneva, Bio-Elpida mainly in Research and pharmaceutical development and aquired a strong expertise in GLP/GMP manufacturing.

Lionel has participated in the development of several drug candidates, particularly in cell therapies in the field of oncology and tissue regeneration.

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INCREASE IMMUNOGENICITY

Brenus’ manufacturing process overpasses the lack of immunogenicity & educates the immune system  with visible and multi-specific targets

More about Haptenization & STC immunogenicity
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REPRESENT HETEROGENEITY OF THE TARGETED INDICATION

Selection criteria of starting material (Allogeneic tumor cell lines)

  • Representative oncogenic drivers (TP53,BRAF,KRAS,…)
  • Cold & hot tumor cell lines
  • Resistances capacities (metabolic ; chemical & physical)
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Increase antigenicity

Brenus’ manufacturing process overpasses the lack of antigenicity & educates the immune system  with a broad & higher quality range of tumor antigens

More about STC Antigenicity
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