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An innovation to mimic patient’s cancer relapsing conditions.
An innovation to mimic patient’s cancer relapsing conditions
Providing a unique value proposal in the field. The successful equation to anticipate disease progression
APC : antigen-presentinf cell, generally dentritic cell
MHC : Major Histocompatibility complex
TCR : T-Cell Receptor
STC platform facilitates the quick generation of new STC treatments to meet patient’s needs in diverse solid tumors indication.
STC – 1010 development: Strong scientific rationale to target other indications
COLORECTAL CANCER
2nd CAUSE OF CANCER MORTALITY WORLDWIDE
OTHER INDICATIONS
STC – 10XX development : Leveraging STC Platform to design first -in-class immuno – oncology products, anticiapting Specific cancers : Ovarian,Lung,Rare cancers…
SOLID TUMOR
STC-1010: our first candidate in metastatic colorectal cancer (mCRC)
STC-1010 targets MSS and MSI-H population.
STC-1010 has a robust and validated preclinical data pack showing:
in colorectal cold and hot mice model
in several model
in colorectal cold and hot mice model
An OFF-THE-SHELF technology allowing control of both time and cost of the manufacturing process.
We are supported by leading figures in clinical immuno-oncology, with 9 early-phase centers committed to the next clinical trial.
“Cancer vaccines continue to show promising clinical results in solid tumors. STC-1010 is a new immunotherapeutic approach based on cancer vaccine mechanism of action for colorectal cancer patients.
In that, “BreAK-CRC” Study is eagerly expected :
CRC is still challenging as current immunotherapies were found only active
in dMMR/MSI-H “hot” CRC.
For the pMMR/MSS population, representing 95% of patients with CRC, there is an important medical need for drugs likely to heat up “cold” tumors and have a real impact for the patient.”
Director of the Early Clinical Unit CLIP2 INCA – CGFL DIJON FR
Director of UMR INSERM 1231 Head of TEAM 1, TIRECs: “Therapies and Immune REsponse
in CancerS” – University of Burgundy DIJON FR
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See Video here
Brenus’ manufacturing process overpasses the lack of immunogenicity & educates the immune system with visible and multi-specific targets
Selection criteria of starting material (Allogeneic tumor cell lines)
Brenus’ manufacturing process overpasses the lack of antigenicity & educates the immune system with a broad & higher quality range of tumor antigens
