An urgent need to anticipate tumor’s evolution & overcome immune evasion

An innovation to mimic patient’s cancer relapsing conditions.

STC Platform

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Access to treatment
Repertoire of targets/ Targets selection
Immunogenicity
Supply Manufacturing

STC allogeneic vaccine

Access to treatment

No tumor biopsy needed, No HLA restriction.

Repertoire of targets/ Targets selection

Mimicking patient’s mechanism of relapse to increase panel of targets. Validation based on proteome. (LC/MS)

Immunogenicity

Enhanced by hyphenation and ghost
cells, maintaining safety.

Supply Manufacturing

“Off-the-shelf” standardized manufacturing, saving cost and time.

Personalized and other cancer vaccine strategies

Access to treatment

Invasive: tumor biopsy needed, HLA restriction.

Repertoire of targets/ Targets selection

Limited / Validation based on gene
extrapolation. (NGC platform)

Immunogenicity

Non immunogenic targets, Potential
safety issues with viral vectors.

Supply Manufacturing

“Patient / Patient”
Complex, long and costly.

INCREASE IMMUNOGENICITY

Brenus’ manufacturing process overpasses the lack of immunogenicity & educates the immune system  with visible and multi-specific targets

REPRESENT HETEROGENEITY OF THE TARGETED INDICATION

Selection criteria of starting material (Allogeneic tumor cell lines)

  • Representative oncogenic drivers (TP53,BRAF,KRAS,…)
  • Cold & hot tumor cell lines
  • Resistances capacities (metabolic ; chemical & physical)

Increase antigenicity

Brenus’ manufacturing process overpasses the lack of antigenicity & educates the immune system  with broad & higher quality range of tumor antigens